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Careful technique is essential to avoid bruising

The peptide is classified as amphiphilic, meaning it has both water-attracting and water-repelling regions, a property related to its mixed hydrophilic and hydrophobic amino acid residues

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Pinched nerves: When the disc is removed, the space between the bodies becomes smaller which results in a greater likelihood of pinching the nerves where they leave the spine

We next repeated this experimental paradigm in Gipr hypo-KO and Gipr hypo-GFP mice, combining the initiation of HFD with a combination of LIRA (or VEH) alone or LIRA (or VEH) plus GIPR antagonist peptide (GIPR-antag)